Expression of SLC6A1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 6 (neurotransmitter transporter), member 1

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013341	CAB022293

GENE INFORMATION
Gene name	SLC6A1 (HGNC Symbol)
Synonyms	GABATHG, GABATR, GAT1
Description	Solute carrier family 6 (neurotransmitter transporter), member 1 (HGNC Symbol)
Entrez gene summary	The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	10992724 - 11039247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157103 (version 83.38)
Entrez gene	6529
UniProt	P30531 (UniProt - Evidence at protein level)
neXtProt	NX_P30531
Antibodypedia	SLC6A1 antibodies

PROTEIN BROWSER

SLC6A1-001	SLC6A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A1-001 ENSP00000287766 ENST00000287766	P30531 [Direct mapping] Sodium- and chloride-dependent GABA transporter 1 A0A024R2G0 [Target identity:100%; Query identity:100%] Transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005332 [gamma-aminobutyric acid:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007612 [learning] GO:0009636 [response to toxic substance] GO:0009744 [response to sucrose] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0010243 [response to organonitrogen compound] GO:0010288 [response to lead ion] GO:0014054 [positive regulation of gamma-aminobutyric acid secretion] GO:0014070 [response to organic cyclic compound] GO:0014074 [response to purine-containing compound] GO:0015812 [gamma-aminobutyric acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0032355 [response to estradiol] GO:0042220 [response to cocaine] GO:0043005 [neuron projection] GO:0051260 [protein homooligomerization] GO:0051592 [response to calcium ion] GO:0051939 [gamma-aminobutyric acid import] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	599 aa 67.1 kDa	No	>9
SLC6A1-002 ENSP00000411689 ENST00000425938	C9J5P8 [Direct mapping] Sodium- and chloride-dependent GABA transporter 1 Show all	Predicted intracellular proteins Show all		39 aa 4 kDa	No	0