Expression of KLHL40 in cancer - Summary

CANCER ATLAS

Gene description

Kelch-like family member 40

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024463	HPA052201

GENE INFORMATION
Gene name	KLHL40 (HGNC Symbol)
Synonyms	KBTBD5, NEM8, SRYP
Description	Kelch-like family member 40 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a BACK domain, a BTB/POZ domain, and 5 Kelch repeats, however, its exact function is not known. The gene and the multi-domain protein structure are conserved across different taxa, including primates, rodents, chicken and zebrafish. [provided by RefSeq, Dec 2012]
Chromosome	3
Cytoband	p22.1
Chromosome location (bp)	42685519 - 42692544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157119 (version 83.38)
Entrez gene	131377
UniProt	Q2TBA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TBA0
Antibodypedia	KLHL40 antibodies

PROTEIN BROWSER

KLHL40-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL40-001 ENSP00000287777 ENST00000287777	Q2TBA0 [Direct mapping] Kelch-like protein 40 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031397 [negative regulation of protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031672 [A band] GO:0031674 [I band] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048741 [skeletal muscle fiber development] Show all	621 aa 69.3 kDa	No	0