Tissue expression of TIMP4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TIMP4
Gene description	TIMP metallopeptidase inhibitor 4
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (breast, adipose tissue)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (breast, adipose tissue)

GENE INFORMATION
Gene name	TIMP4
Synonyms
Description	TIMP metallopeptidase inhibitor 4 (HGNC Symbol)
Entrez gene summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.2
Chromosome location (bp)	12153051 - 12159351
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000157150 (version 83.38)
Entrez gene	7079
UniProt	Q99727 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99727
Antibodypedia	TIMP4 antibodies

PROTEIN BROWSER

TIMP4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIMP4-001 ENSP00000287814 ENST00000287814	Q99727 [Direct mapping] Metalloproteinase inhibitor 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007219 [Notch signaling pathway] GO:0007417 [central nervous system development] GO:0008150 [biological_process] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009725 [response to hormone] GO:0010951 [negative regulation of endopeptidase activity] GO:0030017 [sarcomere] GO:0032496 [response to lipopolysaccharide] GO:0034097 [response to cytokine] GO:0042493 [response to drug] GO:0042698 [ovulation cycle] GO:0043434 [response to peptide hormone] GO:0046872 [metal ion binding] GO:0048553 [negative regulation of metalloenzyme activity] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] Show all	224 aa 25.5 kDa	Yes	0