Cell atlas - NECAP2 - The Human Protein Atlas

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NECAP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	NECAP2
Gene description	NECAP endocytosis associated 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028077
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028077	BJ	Endoplasmic reticulum	Intensity
	HPA028077	U-2 OS	Endoplasmic reticulum	Intensity

GENE INFORMATION
Gene name	NECAP2 (HGNC Symbol)
Synonyms	FLJ10420
Description	NECAP endocytosis associated 2 (HGNC Symbol)
Entrez gene summary	This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	16440672 - 16460078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157191 (version 83.38)
Entrez gene	55707
UniProt	Q9NVZ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVZ3
Antibodypedia	NECAP2 antibodies

PROTEIN BROWSER

NECAP2-001	NECAP2-007	NECAP2-008	NECAP2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NECAP2-001 ENSP00000338746 ENST00000337132	Q9NVZ3 [Direct mapping] Adaptin ear-binding coat-associated protein 2 A0A024QZ81 [Target identity:100%; Query identity:100%] NECAP endocytosis associated 2, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030125 [clathrin vesicle coat] Show all	263 aa 28.3 kDa	No	0
NECAP2-007 ENSP00000407091 ENST00000457722	Q9NVZ3 [Direct mapping] Adaptin ear-binding coat-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030125 [clathrin vesicle coat] Show all	237 aa 25.3 kDa	No	0
NECAP2-008 ENSP00000391942 ENST00000443980	Q9NVZ3 [Direct mapping] Adaptin ear-binding coat-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030125 [clathrin vesicle coat] Show all	273 aa 29.5 kDa	No	0
NECAP2-012 ENSP00000424509 ENST00000504551	D6RB24 [Direct mapping] Adaptin ear-binding coat-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 21.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.