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LRP8

GENERAL INFORMATION

Gene name

 LRP8

Gene description

 Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (thyroid gland, testis, cerebral cortex)
GTEx:Tissue enhanced (testis, thyroid gland)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (thyroid gland, testis, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 LRP8 (HGNC Symbol)

Synonyms

 APOER2, HSZ75190, LRP-8, MCI1

Description

 Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 53242364 - 53328070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157193 (version 83.38)

Entrez gene

 7804

UniProt

 Q14114 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14114

Antibodypedia

 LRP8 antibodies

PROTEIN BROWSER
LRP8-001
LRP8-002
LRP8-003
LRP8-004
LRP8-009
LRP8-011
LRP8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRP8-001
ENSP00000303634
ENST00000306052
Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008035 [high-density lipoprotein particle binding]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019894 [kinesin binding]
GO:0021541 [ammon gyrus development]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0045860 [positive regulation of protein kinase activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [modulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071397 [cellular response to cholesterol]
GO:1900006 [positive regulation of dendrite development]
Show all
 963 aa
105.6 kDa 		Yes 1
LRP8-002
ENSP00000360509
ENST00000371454
Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [modulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]
Show all
 904 aa
99.1 kDa 		Yes 1
LRP8-003
ENSP00000346391
ENST00000354412
Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [modulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]
Show all
 700 aa
77.8 kDa 		Yes 1
LRP8-004
ENSP00000437009
ENST00000465675
E9PP15 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 457 aa
50.9 kDa 		No 1
LRP8-009
ENSP00000436651
ENST00000475501
H0YEV6 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 241 aa
27 kDa 		No 0
LRP8-011
ENSP00000334522
ENST00000347547
Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [modulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]
Show all
 793 aa
88 kDa 		Yes 1
LRP8-201
ENSP00000480025
ENST00000613948
A0A087WW84 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 699 aa
77.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.