Cell atlas - STEAP2 - The Human Protein Atlas

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STEAP2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	STEAP2
Gene description	STEAP family member 2, metalloreductase
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (CAPAN-2, U-138 MG, A549)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA055603
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, U-138 MG, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055603	A-431	No staining
	HPA055603	A549	Vesicles
	HPA055603	U-2 OS	No staining

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000015653 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055603	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	STEAP2 (HGNC Symbol)
Synonyms	IPCA-1, PCANAP1, STAMP1, STMP
Description	STEAP family member 2, metalloreductase (HGNC Symbol)
Entrez gene summary	This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.13
Chromosome location (bp)	90167590 - 90238137
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157214 (version 83.38)
Entrez gene	261729
UniProt	Q8NFT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFT2
Antibodypedia	STEAP2 antibodies

PROTEIN BROWSER

STEAP2-001	STEAP2-002	STEAP2-003	STEAP2-004	STEAP2-006	STEAP2-007	STEAP2-009	STEAP2-010	STEAP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STEAP2-001 ENSP00000287908 ENST00000287908	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	490 aa 56.1 kDa	No	6
STEAP2-002 ENSP00000378123 ENST00000394626	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Q6YPB2 [Target identity:100%; Query identity:100%] Six transmembrane epithelial antigen of the prostate 2, isoform CRA_a; Six transmembrane prostate protein v1 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	454 aa 52.1 kDa	No	6
STEAP2-003 ENSP00000378128 ENST00000394632	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	419 aa 47.9 kDa	No	4
STEAP2-004 ENSP00000378120 ENST00000394622	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	490 aa 56.1 kDa	No	6
STEAP2-006 ENSP00000378125 ENST00000394629	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Q6YPB2 [Target identity:100%; Query identity:100%] Six transmembrane epithelial antigen of the prostate 2, isoform CRA_a; Six transmembrane prostate protein v1 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	454 aa 52.1 kDa	No	6
STEAP2-007 ENSP00000415931 ENST00000426158	C9JHX5 [Direct mapping] Metalloreductase STEAP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	88 aa 9.6 kDa	No	0
STEAP2-009 ENSP00000401783 ENST00000428074	C9JLP2 [Direct mapping] Metalloreductase STEAP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0043231 [intracellular membrane-bounded organelle] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	182 aa 20.3 kDa	No	0
STEAP2-010 ENSP00000384191 ENST00000402625	B5MC02 [Direct mapping] Metalloreductase STEAP2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0043231 [intracellular membrane-bounded organelle] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	403 aa 46 kDa	No	4
STEAP2-201 ENSP00000378119 ENST00000394621	Q8NFT2 [Direct mapping] Metalloreductase STEAP2 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006897 [endocytosis] GO:0008823 [cupric reductase activity] GO:0009725 [response to hormone] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0030140 [trans-Golgi network transport vesicle] GO:0030173 [integral component of Golgi membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0045055 [regulated secretory pathway] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	490 aa 56.1 kDa	No	6

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.