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DHRS4

CANCER ATLAS

Gene description

 Dehydrogenase/reductase (SDR family) member 4

Protein class

 Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA023972

GENE INFORMATION

Gene name

 DHRS4 (HGNC Symbol)

Synonyms

 FLJ11008, humNRDR, SCAD-SRL, SDR-SRL, SDR25C2

Description

 Dehydrogenase/reductase (SDR family) member 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23953586 - 23969279

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157326 (version 83.38)

Entrez gene

 10901

UniProt

 Q9BTZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTZ2

Antibodypedia

 DHRS4 antibodies

PROTEIN BROWSER
DHRS4-001
DHRS4-002
DHRS4-003
DHRS4-004
DHRS4-005
DHRS4-006
DHRS4-007
DHRS4-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHRS4-001
ENSP00000380264
ENST00000397074
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 158 aa
16.9 kDa 		No 0
DHRS4-002
ENSP00000326219
ENST00000313250
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 278 aa
29.5 kDa 		Yes 0
DHRS4-003
ENSP00000380265
ENST00000397075
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 192 aa
20.5 kDa 		No 0
DHRS4-004
ENSP00000440508
ENST00000543741
F5GWZ1 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 155 aa
16.8 kDa 		No 0
DHRS4-005
ENSP00000453367
ENST00000558263
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 188 aa
20.3 kDa 		No 0
DHRS4-006
ENSP00000453983
ENST00000559632
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 199 aa
21 kDa 		No 0
DHRS4-007
ENSP00000452645
ENST00000558581
Q9BTZ2 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006066 [alcohol metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018455 [alcohol dehydrogenase [NAD(P)+] activity]
GO:0031965 [nuclear membrane]
GO:0042180 [cellular ketone metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 244 aa
25.9 kDa 		No 0
DHRS4-008
ENSP00000454099
ENST00000559975
H0YNP7 [Direct mapping]
Dehydrogenase/reductase SDR family member 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
7.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.