Cell atlas - CACNA1D - The Human Protein Atlas

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CACNA1D

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane

Human cell
	Nuclear membrane

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GENERAL INFORMATION
Gene name	CACNA1D
Gene description	Calcium channel, voltage-dependent, L type, alpha 1D subunit
Protein class	Cancer-related genes Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane.
RNA cell category	Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA020215
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane.

Main location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA020215	CACO-2	Nuclear membrane	Intensity
	HPA020215	RT4	Nuclear membrane

GENE INFORMATION
Gene name	CACNA1D (HGNC Symbol)
Synonyms	CACH3, CACN4, CACNL1A2, Cav1.3, CCHL1A2
Description	Calcium channel, voltage-dependent, L type, alpha 1D subunit (HGNC Symbol)
Entrez gene summary	Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	53494656 - 53813733
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157388 (version 83.38)
Entrez gene	776
UniProt	Q01668 (UniProt - Evidence at protein level)
neXtProt	NX_Q01668
Antibodypedia	CACNA1D antibodies

PROTEIN BROWSER

CACNA1D-001	CACNA1D-002	CACNA1D-003	CACNA1D-004	CACNA1D-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1D-001 ENSP00000288139 ENST00000288139	Q01668 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1D Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0030018 [Z disc] GO:0030506 [ankyrin binding] GO:0034220 [ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086007 [voltage-gated calcium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086059 [voltage-gated calcium channel activity involved SA node cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	2181 aa 247.6 kDa	No	>9
CACNA1D-002 ENSP00000409174 ENST00000422281	Q01668 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1D Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0030018 [Z disc] GO:0030506 [ankyrin binding] GO:0034220 [ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086007 [voltage-gated calcium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086059 [voltage-gated calcium channel activity involved SA node cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	2137 aa 242.4 kDa	No	>9
CACNA1D-003 ENSP00000288133 ENST00000350061	Q01668 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1D Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0030018 [Z disc] GO:0030506 [ankyrin binding] GO:0034220 [ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086007 [voltage-gated calcium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086059 [voltage-gated calcium channel activity involved SA node cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	2161 aa 245.1 kDa	No	>9
CACNA1D-004 ENSP00000418014 ENST00000481478	Q59GD8 [Direct mapping] Calcium channel, voltage-dependent, L type, alpha 1D subunit variant; Voltage-dependent L-type calcium channel subunit alpha-1D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1854 aa 211.5 kDa	No	>9
CACNA1D-007 ENSP00000418045 ENST00000481085	H7C4S8 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	264 aa 30.3 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.