Cell atlas - CACNA2D3 - The Human Protein Atlas

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CACNA2D3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CACNA2D3
Gene description	Calcium channel, voltage-dependent, alpha 2/delta subunit 3
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (HeLa, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA030849 , HPA030850
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HeLa, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & cytosol.

Main location

Nucleus (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030849	HEK 293	Nucleus
	HPA030849	HeLa	Nucleoplasm
	HPA030849	U-2 OS	Nucleoplasm
	HPA030850	HeLa	Cytosol
	HPA030850	U-2 OS	Cytosol
	HPA030850	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CACNA2D3 (HGNC Symbol)
Synonyms	HSA272268
Description	Calcium channel, voltage-dependent, alpha 2/delta subunit 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband
Chromosome location (bp)	54122547 - 55074557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157445 (version 83.38)
Entrez gene	55799
UniProt	Q8IZS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZS8
Antibodypedia	CACNA2D3 antibodies

PROTEIN BROWSER

CACNA2D3-001	CACNA2D3-002	CACNA2D3-006	CACNA2D3-201	CACNA2D3-202	CACNA2D3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA2D3-001 ENSP00000419101 ENST00000474759	Q8IZS8 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1091 aa 123 kDa	Yes	2
CACNA2D3-002 ENSP00000417279 ENST00000490478	Q8IZS8 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	997 aa 113 kDa	No	2
CACNA2D3-006 ENSP00000418028 ENST00000492460	C9JAV5 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Show all	Predicted intracellular proteins Show all	GO:0005246 [calcium channel regulator activity] GO:0005891 [voltage-gated calcium channel complex] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	126 aa 14.6 kDa	No	0
CACNA2D3-201 ENSP00000288197 ENST00000288197	Q8IZS8 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1091 aa 123 kDa	Yes	2
CACNA2D3-202 ENSP00000389506 ENST00000415676	Q8IZS8 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1091 aa 123 kDa	Yes	2
CACNA2D3-203 ENSP00000478969 ENST00000620722	Q8IZS8 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	519 aa 59.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.