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CCNB2

GENERAL INFORMATION

Gene name

 CCNB2

Gene description

 Cyclin B2

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008873 , CAB009575
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 CCNB2 (HGNC Symbol)

Synonyms

 HsT17299

Description

 Cyclin B2 (HGNC Symbol)

Entrez gene summary

 Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 59105078 - 59125045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157456 (version 83.38)

Entrez gene

 9133

UniProt

 O95067 (UniProt - Evidence at protein level)

neXtProt

 NX_O95067

Antibodypedia

 CCNB2 antibodies

PROTEIN BROWSER
CCNB2-001
CCNB2-002
CCNB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNB2-001
ENSP00000288207
ENST00000288207
O95067 [Direct mapping]
G2/mitotic-specific cyclin-B2
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0040007 [growth]
GO:0043029 [T cell homeostasis]
GO:0048538 [thymus development]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
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 398 aa
45.3 kDa 		No 0
CCNB2-002
ENSP00000453685
ENST00000559622
H0YMP3 [Direct mapping]
G2/mitotic-specific cyclin-B2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 270 aa
31.2 kDa 		No 0
CCNB2-201
ENSP00000480809
ENST00000621385
H1UBN3 [Direct mapping]
Cyclin B2; G2/mitotic-specific cyclin-B2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 374 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.