Expression of APPL1 in cancer - Summary

CANCER ATLAS

Gene description

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA011138

GENE INFORMATION
Gene name	APPL1 (HGNC Symbol)
Synonyms	APPL
Description	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	57227737 - 57273468
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157500 (version 83.38)
Entrez gene	26060
UniProt	Q9UKG1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKG1
Antibodypedia	APPL1 antibodies

PROTEIN BROWSER

APPL1-001	APPL1-002	APPL1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APPL1-001 ENSP00000288266 ENST00000288266	Q9UKG1 [Direct mapping] DCC-interacting protein 13-alpha Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0012501 [programmed cell death] GO:0012506 [vesicle membrane] GO:0016581 [NuRD complex] GO:0031901 [early endosome membrane] GO:0042802 [identical protein binding] GO:0043422 [protein kinase B binding] GO:0046324 [regulation of glucose import] GO:0070062 [extracellular exosome] GO:0090003 [regulation of establishment of protein localization to plasma membrane] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	709 aa 79.7 kDa	No	0
APPL1-002 ENSP00000406095 ENST00000444459	C9JAB0 [Direct mapping] DCC-interacting protein 13-alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.3 kDa	No	0
APPL1-008 ENSP00000419644 ENST00000495803	C9K0C4 [Direct mapping] DCC-interacting protein 13-alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	No	0