Cell atlas - TSC22D3 - The Human Protein Atlas

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TSC22D3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nuclear speckles

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TSC22D3
Gene description	TSC22 domain family, member 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the Golgi apparatus & nuclear speckles.
RNA cell category	Cell line enhanced (hTCEpi, Karpas-707, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nuclear speckles (approved), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001916
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, Karpas-707, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the Golgi apparatus & nuclear speckles.

Main location

Cytosol (approved)

Additional location

Nuclear speckles (approved), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001916	A-431	Nuclear speckles
			Golgi apparatus
			Cytosol
	HPA001916	U-2 OS	Nuclear speckles
	HPA001916	U-2 OS	Cytosol
	HPA001916	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TSC22D3 (HGNC Symbol)
Synonyms	DIP, DSIPI, GILZ, hDIP, TSC-22R
Description	TSC22 domain family, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	107713221 - 107777342
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157514 (version 83.38)
Entrez gene	1831
UniProt	Q99576 (UniProt - Evidence at protein level)
neXtProt	NX_Q99576
Antibodypedia	TSC22D3 antibodies

PROTEIN BROWSER

TSC22D3-001	TSC22D3-002	TSC22D3-003	TSC22D3-004	TSC22D3-005	TSC22D3-006	TSC22D3-007	TSC22D3-008	TSC22D3-009	TSC22D3-010	TSC22D3-011	TSC22D3-012	TSC22D3-013	TSC22D3-014	TSC22D3-015	TSC22D3-016	TSC22D3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSC22D3-001 ENSP00000361474 ENST00000372397	Q99576 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	134 aa 14.8 kDa	No	0
TSC22D3-002 ENSP00000361466 ENST00000372390	Q5JRJ2 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	77 aa 8.7 kDa	No	0
TSC22D3-003 ENSP00000361457 ENST00000372382	Q5JRJ0 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	110 aa 12.3 kDa	No	0
TSC22D3-004 ENSP00000361458 ENST00000372383	Q99576 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006970 [response to osmotic stress] GO:0034220 [ion transmembrane transport] GO:0043426 [MRF binding] GO:0048642 [negative regulation of skeletal muscle tissue development] GO:0055085 [transmembrane transport] GO:0070236 [negative regulation of activation-induced cell death of T cells] Show all	200 aa 22.2 kDa	No	0
TSC22D3-005 ENSP00000361459 ENST00000372384	Q99576 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	200 aa 22.2 kDa	No	0
TSC22D3-006 ENSP00000425414 ENST00000486554	D6RD92 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	25 aa 3.1 kDa	No	0
TSC22D3-007 ENSP00000427427 ENST00000506081	Q99576 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	200 aa 22.2 kDa	No	0
TSC22D3-008 ENSP00000314655 ENST00000315660	Q99576 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	200 aa 22.2 kDa	No	0
TSC22D3-009 ENSP00000424653 ENST00000502650	D6RAX8 [Direct mapping] TSC22 domain family protein 3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	116 aa 12.8 kDa	No	0
TSC22D3-010 ENSP00000427075 ENST00000506724	D6RD37 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 11.1 kDa	No	0
TSC22D3-011 ENSP00000425155 ENST00000480691	D6RDZ9 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	123 aa 13.6 kDa	No	0
TSC22D3-012 ENSP00000422636 ENST00000510887	D6RBL1 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	119 aa 13.1 kDa	No	0
TSC22D3-013 ENSP00000427199 ENST00000514897	D6RCK9 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	124 aa 13.7 kDa	No	0
TSC22D3-014 ENSP00000422228 ENST00000502961	D6R8Z7 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.3 kDa	No	0
TSC22D3-015 ENSP00000425158 ENST00000505965	D6RDZ7 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	84 aa 9.3 kDa	No	0
TSC22D3-016 ENSP00000421016 ENST00000514426	E7EWD5 [Direct mapping] TSC22 domain family protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	132 aa 14.8 kDa	No	0
TSC22D3-017 ENSP00000422060 ENST00000503515	D6R9J1 [Direct mapping] TSC22 domain family protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 10.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.