Tissue expression of KCNJ6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNJ6
Gene description	Potassium channel, inwardly rectifying subfamily J, member 6
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebellum, hippocampus, cerebral cortex, pituitary gland, hypothalamus)
FANTOM5:	Group enriched (cerebellum, pituitary gland, hippocampus, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus, cerebral cortex, pituitary gland, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, pituitary gland, hippocampus, brain)

GENE INFORMATION
Gene name	KCNJ6 (HGNC Symbol)
Synonyms	BIR1, GIRK2, hiGIRK2, KATP2, KCNJ7, Kir3.2
Description	Potassium channel, inwardly rectifying subfamily J, member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
Chromosome	21
Cytoband	q22.13
Chromosome location (bp)	37607376 - 37916446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157542 (version 83.38)
Entrez gene	3763
UniProt	P48051 (UniProt - Evidence at protein level)
neXtProt	NX_P48051
Antibodypedia	KCNJ6 antibodies

PROTEIN BROWSER

KCNJ6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ6-001 ENSP00000477437 ENST00000609713	P48051 [Direct mapping] G protein-activated inward rectifier potassium channel 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015467 [G-protein activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	423 aa 48.5 kDa	No	2