Cell atlas - KCNJ15 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNJ15
Gene description	Potassium channel, inwardly rectifying subfamily J, member 15
Protein class	Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & vesicles.
RNA cell category	Group enriched (RT4, RPTEC TERT1, ASC TERT1, LHCN-M2, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Vesicles (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016702
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RT4, RPTEC TERT1, ASC TERT1, LHCN-M2, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & vesicles.

Main location

Plasma membrane (approved)

Additional location

Vesicles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA016702	A-431	Plasma membrane
HPA016702	RT4	Vesicles
HPA016702	U-2 OS	Plasma membrane
HPA016702	U-2 OS	Cytosol

GENE INFORMATION
Gene name	KCNJ15 (HGNC Symbol)
Synonyms	IRKK, Kir1.3, Kir4.2
Description	Potassium channel, inwardly rectifying subfamily J, member 15 (HGNC Symbol)
Entrez gene summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Chromosome	21
Cytoband
Chromosome location (bp)	38157034 - 38307357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157551 (version 83.38)
Entrez gene	3772
UniProt	Q99712 (UniProt - Evidence at protein level)
neXtProt	NX_Q99712
Antibodypedia	KCNJ15 antibodies

PROTEIN BROWSER

KCNJ15-001	KCNJ15-002	KCNJ15-003	KCNJ15-004	KCNJ15-005	KCNJ15-006	KCNJ15-007	KCNJ15-008	KCNJ15-009	KCNJ15-010	KCNJ15-011	KCNJ15-012	KCNJ15-013	KCNJ15-014	KCNJ15-015	KCNJ15-016	KCNJ15-017	KCNJ15-018	KCNJ15-201	KCNJ15-202	KCNJ15-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ15-001 ENSP00000331698 ENST00000328656	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-002 ENSP00000381911 ENST00000398938	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-003 ENSP00000381905 ENST00000398932	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-004 ENSP00000381904 ENST00000398930	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-005 ENSP00000413013 ENST00000443341	C9JTX1 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	39 aa 4.1 kDa	No	0
KCNJ15-006 ENSP00000381902 ENST00000398928	A8MVK1 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	156 aa 17.4 kDa	No	2
KCNJ15-007 ENSP00000381899 ENST00000398925	A8MTZ5 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	61 aa 6.7 kDa	No	0
KCNJ15-008 ENSP00000392951 ENST00000417042	C9J0W5 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0010107 [potassium ion import] GO:0034765 [regulation of ion transmembrane transport] Show all	19 aa 2 kDa	No	0
KCNJ15-009 ENSP00000381901 ENST00000398927	A8MVK1 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	156 aa 17.4 kDa	No	2
KCNJ15-010 ENSP00000414487 ENST00000438657	E7EPG3 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	245 aa 27.3 kDa	No	2
KCNJ15-011 ENSP00000400849 ENST00000419868	E7EWV2 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	139 aa 15.6 kDa	No	1
KCNJ15-012 ENSP00000448770 ENST00000549805	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-013 ENSP00000447111 ENST00000547341	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-014 ENSP00000449140 ENST00000549158	F8VW46 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	25 aa 2.5 kDa	No	0
KCNJ15-015 ENSP00000448676 ENST00000549932	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-016 ENSP00000450254 ENST00000547595	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-017 ENSP00000448886 ENST00000548700	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-018 ENSP00000449419 ENST00000551422	F8VX74 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Predicted intracellular proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	48 aa 5.1 kDa	No	0
KCNJ15-201 ENSP00000381907 ENST00000398934	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-202 ENSP00000484960 ENST00000612702	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2
KCNJ15-203 ENSP00000479100 ENST00000613499	Q99712 [Direct mapping] ATP-sensitive inward rectifier potassium channel 15 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	375 aa 42.6 kDa	No	2