Cell atlas - SLC35B2 - The Human Protein Atlas

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SLC35B2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC35B2
Gene description	Solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA029638
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029638	U-2 OS	Vesicles
	HPA029638	U-251 MG	Vesicles

GENE INFORMATION
Gene name	SLC35B2 (HGNC Symbol)
Synonyms	UGTrel4
Description	Solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 (HGNC Symbol)
Entrez gene summary	Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44254096 - 44257890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157593 (version 83.38)
Entrez gene	347734
UniProt	Q8TB61 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TB61
Antibodypedia	SLC35B2 antibodies

PROTEIN BROWSER

SLC35B2-002	SLC35B2-003	SLC35B2-201	SLC35B2-202	SLC35B2-203	SLC35B2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35B2-002 ENSP00000377401 ENST00000393812	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	432 aa 47.5 kDa	Yes	>9
SLC35B2-003 ENSP00000377399 ENST00000393810	A0A0A0MS46 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.4 kDa	Yes	1
SLC35B2-201 ENSP00000440340 ENST00000537814	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	299 aa 32.7 kDa	No	8
SLC35B2-202 ENSP00000443845 ENST00000538577	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	339 aa 37.2 kDa	Yes	8
SLC35B2-203 ENSP00000480681 ENST00000615337	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	383 aa 42.1 kDa	No	8
SLC35B2-204 ENSP00000483181 ENST00000619636	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	383 aa 42.1 kDa	No	8

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.