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DGKI

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GENERAL INFORMATION

Gene name

 DGKI

Gene description

 Diacylglycerol kinase, iota

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (U-2197, SCLC-21H, U-87 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA021924
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197, SCLC-21H, U-87 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021924 A-431 Nucleoplasm
HPA021924 U-2 OS Nucleoplasm Intensity
HPA021924 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 DGKI (HGNC Symbol)

Synonyms

 DGK-IOTA

Description

 Diacylglycerol kinase, iota (HGNC Symbol)

Entrez gene summary

 This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 137381037 - 137847092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157680 (version 83.38)

Entrez gene

 9162

UniProt

 O75912 (UniProt - Evidence at protein level)

neXtProt

 NX_O75912

Antibodypedia

 DGKI antibodies

PROTEIN BROWSER
DGKI-001
DGKI-002
DGKI-003
DGKI-014
DGKI-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKI-001
ENSP00000288490
ENST00000288490
O75912 [Direct mapping]
Diacylglycerol kinase iota
Show all
Enzymes
   ENZYME proteins
   Transferases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007269 [neurotransmitter secretion]
GO:0007596 [blood coagulation]
GO:0008021 [synaptic vesicle]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0017016 [Ras GTPase binding]
GO:0030168 [platelet activation]
GO:0032045 [guanyl-nucleotide exchange factor complex]
GO:0034260 [negative regulation of GTPase activity]
GO:0035556 [intracellular signal transduction]
GO:0043025 [neuronal cell body]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0046959 [habituation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048786 [presynaptic active zone]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0097060 [synaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:1900452 [regulation of long term synaptic depression]
Show all
 1065 aa
117 kDa 		No 0
DGKI-002
ENSP00000392161
ENST00000453654
E9PFX6 [Direct mapping]
Diacylglycerol kinase
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 734 aa
82.2 kDa 		No 0
DGKI-003
ENSP00000399131
ENST00000446122
E7EM72 [Direct mapping]
Diacylglycerol kinase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 1047 aa
115.1 kDa 		No 0
DGKI-014
ENSP00000396078
ENST00000424189
E7EWQ4 [Direct mapping]
Diacylglycerol kinase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 1078 aa
118.5 kDa 		No 0
DGKI-201
ENSP00000479053
ENST00000614521
A0A087WV00 [Direct mapping]
Diacylglycerol kinase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 932 aa
104.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.