Expression of ACAN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Aggrecan

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038241	HPA038242	CAB016377

GENE INFORMATION
Gene name	ACAN (HGNC Symbol)
Synonyms	AGC1, CSPG1, CSPGCP, MSK16
Description	Aggrecan (HGNC Symbol)
Entrez gene summary	This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	88803443 - 88875354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157766 (version 83.38)
Entrez gene	176
UniProt
neXtProt
Antibodypedia	ACAN antibodies

PROTEIN BROWSER

ACAN-001	ACAN-003	ACAN-004	ACAN-005	ACAN-006	ACAN-008	ACAN-201	ACAN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAN-001 ENSP00000453003 ENST00000558207	Q6PID9 [Direct mapping] Aggrecan; Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	721 aa 79.6 kDa	Yes	0
ACAN-003 ENSP00000452682 ENST00000558704	H0YK70 [Direct mapping] Aggrecan core protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	156 aa 17.3 kDa	No	0
ACAN-004 ENSP00000341615 ENST00000352105	E7ENV9 [Direct mapping] Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	2431 aa 250.4 kDa	Yes	0
ACAN-005 ENSP00000453581 ENST00000560601	H0YMF1 [Direct mapping] Aggrecan core protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	226 aa 24.2 kDa	No	0
ACAN-006 ENSP00000453342 ENST00000561243	E7EX88 [Direct mapping] Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	2530 aa 261.3 kDa	Yes	0
ACAN-008 ENSP00000453499 ENST00000559004	H0YM81 [Direct mapping] Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	2492 aa 257.4 kDa	Yes	0
ACAN-201 ENSP00000387356 ENST00000439576	E7EX88 [Direct mapping] Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0002063 [chondrocyte development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0030166 [proteoglycan biosynthetic process] GO:0030199 [collagen fibril organization] Show all	2530 aa 261.3 kDa	Yes	0
ACAN-202 ENSP00000484456 ENST00000617301	A0A087X1T7 [Direct mapping] Aggrecan core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	2473 aa 255.6 kDa	Yes	0