Cell atlas - WDR19 - The Human Protein Atlas

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WDR19

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	WDR19
Gene description	WD repeat domain 19
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Cell line enhanced (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA039616 , HPA058847
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039616	A-431	Nucleoplasm
	HPA039616	A-431	Nuclear bodies
	HPA039616	U-2 OS	Nucleoplasm
	HPA039616	U-2 OS	Nuclear bodies
	HPA039616	U-251 MG	Nuclear bodies
	HPA058847	HeLa	Nucleoplasm
	HPA058847	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	WDR19 (HGNC Symbol)
Synonyms	DYF-2, FLJ23127, IFT144, KIAA1638, NPHP13, ORF26, Oseg6, Pwdmp
Description	WD repeat domain 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	39182404 - 39285810
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157796 (version 83.38)
Entrez gene	57728
UniProt	Q8NEZ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEZ3
Antibodypedia	WDR19 antibodies

PROTEIN BROWSER

WDR19-001	WDR19-006	WDR19-010	WDR19-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR19-001 ENSP00000382717 ENST00000399820	Q8NEZ3 [Direct mapping] WD repeat-containing protein 19 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005929 [cilium] GO:0006996 [organelle organization] GO:0030991 [intraciliary transport particle A] GO:0031513 [nonmotile primary cilium] GO:0031514 [motile cilium] GO:0032391 [photoreceptor connecting cilium] GO:0035721 [intraciliary retrograde transport] GO:0042384 [cilium assembly] GO:0072372 [primary cilium] GO:0097542 [ciliary tip] Show all	1342 aa 151.6 kDa	No	0
WDR19-006 ENSP00000423491 ENST00000506503	D6R9P6 [Direct mapping] WD repeat domain 19, isoform CRA_a; WD repeat-containing protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005929 [cilium] GO:0042384 [cilium assembly] Show all	481 aa 53.6 kDa	No	0
WDR19-010 ENSP00000426918 ENST00000509560	D6RE75 [Direct mapping] WD repeat-containing protein 19 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005929 [cilium] GO:0042384 [cilium assembly] Show all	142 aa 15.9 kDa	No	0
WDR19-011 ENSP00000421888 ENST00000512112	D6RAI4 [Direct mapping] WD repeat-containing protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005929 [cilium] GO:0042384 [cilium assembly] Show all	42 aa 4.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.