Expression of PEX10 in cancer - Summary

CANCER ATLAS

Gene description

Peroxisomal biogenesis factor 10

Protein class

Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049755

GENE INFORMATION
Gene name	PEX10 (HGNC Symbol)
Synonyms	RNF69
Description	Peroxisomal biogenesis factor 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	2403964 - 2413797
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157911 (version 83.38)
Entrez gene	5192
UniProt	O60683 (UniProt - Evidence at protein level)
neXtProt	NX_O60683
Antibodypedia	PEX10 antibodies

PROTEIN BROWSER

PEX10-001	PEX10-002	PEX10-003	PEX10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX10-001 ENSP00000288774 ENST00000288774	O60683 [Direct mapping] Peroxisome biogenesis factor 10 A0A024R0A4 [Target identity:100%; Query identity:100%] Peroxisome biogenesis factor 10, isoform CRA_b Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0008270 [zinc ion binding] GO:0016558 [protein import into peroxisome matrix] Show all	346 aa 39.2 kDa	No	2
PEX10-002 ENSP00000407922 ENST00000447513	O60683 [Direct mapping] Peroxisome biogenesis factor 10 A0A024R068 [Target identity:100%; Query identity:100%] Peroxisome biogenesis factor 10, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0008270 [zinc ion binding] GO:0016558 [protein import into peroxisome matrix] Show all	326 aa 37.1 kDa	No	2
PEX10-003 ENSP00000424291 ENST00000507596	D6RBB0 [Direct mapping] Peroxisome biogenesis factor 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005779 [integral component of peroxisomal membrane] GO:0008270 [zinc ion binding] GO:0016558 [protein import into peroxisome matrix] Show all	324 aa 36.9 kDa	No	2
PEX10-004 ENSP00000464289 ENST00000508384	J3QRM4 [Direct mapping] Peroxisome biogenesis factor 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.5 kDa	No	0