Cell atlas - RER1 - The Human Protein Atlas

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RER1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	RER1
Gene description	Retention in endoplasmic reticulum sorting receptor 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB037240 , HPA051400
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB037240	A-431	Golgi apparatus
	CAB037240	U-2 OS	No staining
	CAB037240	U-251 MG	No staining
	HPA051400	A-431	Golgi apparatus
	HPA051400	HeLa	No staining
	HPA051400	U-2 OS	Golgi apparatus	Intensity

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000029048 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051400	NIH 3T3	No staining

GENE INFORMATION
Gene name	RER1
Synonyms
Description	Retention in endoplasmic reticulum sorting receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	2391775 - 2405444
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157916 (version 83.38)
Entrez gene	11079
UniProt	O15258 (UniProt - Evidence at protein level)
neXtProt	NX_O15258
Antibodypedia	RER1 antibodies

PROTEIN BROWSER

RER1-001	RER1-002	RER1-003	RER1-004	RER1-006	RER1-008	RER1-201	RER1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RER1-001 ENSP00000475168 ENST00000605895	O15258 [Direct mapping] Protein RER1 Q5T094 [Target identity:100%; Query identity:100%] RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae), isoform CRA_a; Similar to S. cerevisiae RER1; cDNA FLJ78405, highly similar to Homo sapiens RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae), mRNA Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0007528 [neuromuscular junction development] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0030173 [integral component of Golgi membrane] GO:0033130 [acetylcholine receptor binding] GO:0071340 [skeletal muscle acetylcholine-gated channel clustering] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] Show all	196 aa 23 kDa	No	3
RER1-002 ENSP00000367773 ENST00000378512	Q5T091 [Direct mapping] Protein RER1; RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	187 aa 21 kDa	No	2
RER1-003 ENSP00000464222 ENST00000488353	O15258 [Direct mapping] Protein RER1 Q5T094 [Target identity:100%; Query identity:100%] RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae), isoform CRA_a; Similar to S. cerevisiae RER1; cDNA FLJ78405, highly similar to Homo sapiens RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae), mRNA Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005794 [Golgi apparatus] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0016021 [integral component of membrane] GO:0030173 [integral component of Golgi membrane] Show all	196 aa 23 kDa	No	3
RER1-004 ENSP00000367779 ENST00000378518	Q5T093 [Direct mapping] Protein RER1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 13.4 kDa	No	1
RER1-006 ENSP00000417000 ENST00000443438	Q5T092 [Direct mapping] Protein RER1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	158 aa 18.4 kDa	No	3
RER1-008 ENSP00000302088 ENST00000306256	A0A0A0MR06 [Direct mapping] Protein RER1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	177 aa 20.8 kDa	No	3
RER1-201 ENSP00000367774 ENST00000378513	Q5T093 [Direct mapping] Protein RER1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 13.4 kDa	No	1
RER1-202 ENSP00000487501 ENST00000630837	Q9P0H9 [Direct mapping] Protein RER1; RER1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	214 aa 24.8 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.