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Cancer tissues were in general negative or displayed weak cytoplasmic staining. Gliomas and testicular cancers displayed strong cytoplasmic immunoreactivity, in a few cases accompanied with nuclear staining.
GENE INFORMATION
Gene name
LDLRAP1 (HGNC Symbol)
Synonyms
ARH, ARH2, DKFZp586D0624, FHCB1, FHCB2, MGC34705
Description
Low density lipoprotein receptor adaptor protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]