Expression of MRPL17 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L17

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043666	HPA050552

GENE INFORMATION
Gene name	MRPL17 (HGNC Symbol)
Synonyms	MRP-L26, RPML26
Description	Mitochondrial ribosomal protein L17 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6680782 - 6683401
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158042 (version 83.38)
Entrez gene	63875
UniProt	Q9NRX2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRX2
Antibodypedia	MRPL17 antibodies

PROTEIN BROWSER

MRPL17-001	MRPL17-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL17-001 ENSP00000288937 ENST00000288937	Q9NRX2 [Direct mapping] 39S ribosomal protein L17, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000002 [mitochondrial genome maintenance] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0019904 [protein domain specific binding] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	175 aa 20.1 kDa	No	0
MRPL17-004 ENSP00000435294 ENST00000532203	E9PKV2 [Direct mapping] 39S ribosomal protein L17, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000002 [mitochondrial genome maintenance] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] Show all	142 aa 16.4 kDa	No	0