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A few cases of colorectal and stomach cancers displayed moderate luminal membranous staining. Moderate nuclear positivity was observed in occasional cases of cervical and urothelial cancers. Occasional cases of melanomas displayed moderate cytoplasmic staining. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
EYA3 (HGNC Symbol)
Synonyms
DKFZp686C132
Description
EYA transcriptional coactivator and phosphatase 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)