Expression of FANCC in cancer - Summary

CANCER ATLAS

Gene description

Fanconi anemia, complementation group C

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB017793

GENE INFORMATION
Gene name	FANCC (HGNC Symbol)
Synonyms	FA3, FAC, FACC
Description	Fanconi anemia, complementation group C (HGNC Symbol)
Entrez gene summary	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q22.32
Chromosome location (bp)	95099054 - 95317709
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158169 (version 83.38)
Entrez gene	2176
UniProt	Q00597 (UniProt - Evidence at protein level)
neXtProt	NX_Q00597
Antibodypedia	FANCC antibodies

PROTEIN BROWSER

FANCC-001	FANCC-002	FANCC-004	FANCC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FANCC-001 ENSP00000289081 ENST00000289081	Q00597 [Direct mapping] Fanconi anemia group C protein A0A024R9N2 [Target identity:100%; Query identity:100%] Fanconi anemia, complementation group C, isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0002262 [myeloid cell homeostasis] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006461 [protein complex assembly] GO:0007276 [gamete generation] GO:0007281 [germ cell development] GO:0019430 [removal of superoxide radicals] GO:0036297 [interstrand cross-link repair] GO:0043240 [Fanconi anaemia nuclear complex] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	558 aa 63.4 kDa	No	0
FANCC-002 ENSP00000364454 ENST00000375305	Q00597 [Direct mapping] Fanconi anemia group C protein A0A024R9N2 [Target identity:100%; Query identity:100%] Fanconi anemia, complementation group C, isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006461 [protein complex assembly] GO:0036297 [interstrand cross-link repair] GO:0043240 [Fanconi anaemia nuclear complex] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	558 aa 63.4 kDa	No	0
FANCC-004 ENSP00000406908 ENST00000433829	B1ALR7 [Direct mapping] Fanconi anemia group C protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] Show all	150 aa 17.3 kDa	No	0
FANCC-201 ENSP00000479931 ENST00000490972	A0A087WW44 [Direct mapping] Fanconi anemia group C protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] Show all	492 aa 56.1 kDa	No	0