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COLEC12

CANCER ATLAS

Gene description

 Collectin sub-family member 12

Protein class

 Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047917

GENE INFORMATION

Gene name

 COLEC12 (HGNC Symbol)

Synonyms

 CL-P1, SCARA4, SRCL

Description

 Collectin sub-family member 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 316740 - 500722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158270 (version 83.38)

Entrez gene

 81035

UniProt

 Q5KU26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5KU26

Antibodypedia

 COLEC12 antibodies

PROTEIN BROWSER
COLEC12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COLEC12-001
ENSP00000383115
ENST00000400256
Q5KU26 [Direct mapping]
Collectin-12
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0005534 [galactose binding]
GO:0005581 [collagen trimer]
GO:0005886 [plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006910 [phagocytosis, recognition]
GO:0006952 [defense response]
GO:0006955 [immune response]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0009756 [carbohydrate mediated signaling]
GO:0016021 [integral component of membrane]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030666 [endocytic vesicle membrane]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051260 [protein homooligomerization]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0070062 [extracellular exosome]
GO:0071360 [cellular response to exogenous dsRNA]
Show all
 742 aa
81.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.