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Colorectal and pancreatic cancers along with several gastric cancers displayed moderate to strong cytoplasmic and/or membranous positivity. Several malignant gliomas, breast, ovarian and prostate cancers were moderately stained. Remaining malignant cells were in general weakly stained or negative.
The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
