Expression of CD1D in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

CD1d molecule

Protein class

Cancer-related genes, CD markers, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB016107

GENE INFORMATION
Gene name	CD1D
Synonyms
Description	CD1d molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	158179947 - 158184896
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158473 (version 83.38)
Entrez gene	912
UniProt	P15813 (UniProt - Evidence at protein level)
neXtProt	NX_P15813
Antibodypedia	CD1D antibodies

PROTEIN BROWSER

CD1D-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD1D-001 ENSP00000357153 ENST00000368171	P15813 [Direct mapping] Antigen-presenting glycoprotein CD1d Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016032 [viral process] GO:0016045 [detection of bacterium] GO:0030881 [beta-2-microglobulin binding] GO:0030882 [lipid antigen binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0034113 [heterotypic cell-cell adhesion] GO:0042102 [positive regulation of T cell proliferation] GO:0042393 [histone binding] GO:0045058 [T cell selection] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0048006 [antigen processing and presentation, endogenous lipid antigen via MHC class Ib] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0050839 [cell adhesion molecule binding] GO:0071723 [lipopeptide binding] Show all	335 aa 37.7 kDa	Yes	1