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Most prostate, thyroid and liver cancers as well as several colorectal, breast, urothelial and stomach cancers showed moderate to strong cytoplasmic staining. Several lung and pancreatic cancers showed moderate cytoplasmic positivity. Remaining cancers were generally weakly stained or negative.
GENE INFORMATION
Gene name
CD1B (HGNC Symbol)
Synonyms
CD1
Description
CD1b molecule (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
