Cell atlas - ELK4 - The Human Protein Atlas

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ELK4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ELK4
Gene description	ELK4, ETS-domain protein (SRF accessory protein 1)
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028863
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028863	A-431	Nucleoplasm
	HPA028863	U-2 OS	Nucleoplasm
	HPA028863	U-251 MG	Nucleoplasm
	HPA028863	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ELK4 (HGNC Symbol)
Synonyms	SAP1
Description	ELK4, ETS-domain protein (SRF accessory protein 1) (HGNC Symbol)
Entrez gene summary	This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	205597556 - 205631962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158711 (version 83.38)
Entrez gene	2005
UniProt	P28324 (UniProt - Evidence at protein level)
neXtProt	NX_P28324
Antibodypedia	ELK4 antibodies

PROTEIN BROWSER

ELK4-001	ELK4-002	ELK4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELK4-001 ENSP00000350681 ENST00000357992	P28324 [Direct mapping] ETS domain-containing protein Elk-4 A0A024R9C2 [Target identity:100%; Query identity:100%] ELK4, ETS-domain protein (SRF accessory protein 1), isoform CRA_b Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0070932 [histone H3 deacetylation] Show all	431 aa 46.9 kDa	No	0
ELK4-002 ENSP00000289703 ENST00000289703	P28324 [Direct mapping] ETS domain-containing protein Elk-4 A0A024R997 [Target identity:100%; Query identity:100%] ELK4, ETS-domain protein (SRF accessory protein 1), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0070932 [histone H3 deacetylation] Show all	405 aa 44.7 kDa	No	0
ELK4-003 ENSP00000484946 ENST00000468523	A0A087X2F7 [Direct mapping] ETS domain-containing protein Elk-4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	144 aa 16.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.