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F11R

GENERAL INFORMATION

Gene name

 F11R

Gene description

 F11 receptor

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Not detected
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cell membrane expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA061700 , CAB004671
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 F11R (HGNC Symbol)

Synonyms

 CD321, JAM-1, JAM-A, JAM1, JAMA, JCAM, PAM-1

Description

 F11 receptor (HGNC Symbol)

Entrez gene summary

 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 160995211 - 161021348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158769 (version 83.38)

Entrez gene

 50848

UniProt

 Q9Y624 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y624

Antibodypedia

 F11R antibodies

PROTEIN BROWSER
F11R-001
F11R-002
F11R-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
F11R-001
ENSP00000357005
ENST00000368026
Q9Y624 [Direct mapping]
Junctional adhesion molecule A
Q6FIB4 [Target identity:100%; Query identity:100%]
F11 receptor; F11 receptor protein; F11 receptor, isoform CRA_c; F11R protein; JAM1; cDNA FLJ90671 fis, clone PLACE1005544, highly similar to Junctional adhesion molecule 1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001817 [regulation of cytokine production]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009314 [response to radiation]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030165 [PDZ domain binding]
GO:0030198 [extracellular matrix organization]
GO:0030855 [epithelial cell differentiation]
GO:0031032 [actomyosin structure organization]
GO:0031410 [cytoplasmic vesicle]
GO:0034260 [negative regulation of GTPase activity]
GO:0034329 [cell junction assembly]
GO:0036057 [slit diaphragm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045216 [cell-cell junction organization]
GO:0045777 [positive regulation of blood pressure]
GO:0046718 [viral entry into host cell]
GO:0050892 [intestinal absorption]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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 299 aa
32.6 kDa 		Yes 1
F11R-002
ENSP00000440812
ENST00000537746
Q9Y624 [Direct mapping]
Junctional adhesion molecule A
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006954 [inflammatory response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030198 [extracellular matrix organization]
GO:0031032 [actomyosin structure organization]
GO:0034260 [negative regulation of GTPase activity]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045216 [cell-cell junction organization]
GO:0046718 [viral entry into host cell]
GO:0050892 [intestinal absorption]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 250 aa
27.2 kDa 		Yes 1
F11R-201
ENSP00000481591
ENST00000621309
A0A087WY82 [Direct mapping]
Junctional adhesion molecule A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 279 aa
30.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.