Tissue expression of DEDD - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DEDD
Gene description	Death effector domain containing
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DEDD (HGNC Symbol)
Synonyms	CASP8IP1, DEDD1, DEFT, FLDED1, KE05
Description	Death effector domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161120974 - 161132688
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158796 (version 83.38)
Entrez gene	9191
UniProt	O75618 (UniProt - Evidence at protein level)
neXtProt	NX_O75618
Antibodypedia	DEDD antibodies

PROTEIN BROWSER

DEDD-001	DEDD-002	DEDD-006	DEDD-010	DEDD-201	DEDD-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEDD-001 ENSP00000356985 ENST00000368006	O75618 [Direct mapping] Death effector domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007283 [spermatogenesis] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0042177 [negative regulation of protein catabolic process] GO:0042981 [regulation of apoptotic process] GO:0046697 [decidualization] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] Show all	318 aa 36.8 kDa	No	0
DEDD-002 ENSP00000356984 ENST00000368005	B1AQP5 [Direct mapping] Death effector domain containing, isoform CRA_b; Death effector domain-containing protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process] Show all	348 aa 40.4 kDa	No	0
DEDD-006 ENSP00000476946 ENST00000490843	O75618 [Direct mapping] Death effector domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0042981 [regulation of apoptotic process] Show all	318 aa 36.8 kDa	No	0
DEDD-010 ENSP00000476316 ENST00000464113	V9GY27 [Direct mapping] Death effector domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process] Show all	287 aa 33.2 kDa	No	0
DEDD-201 ENSP00000414821 ENST00000458050	O75618 [Direct mapping] Death effector domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0042981 [regulation of apoptotic process] Show all	318 aa 36.8 kDa	No	0
DEDD-202 ENSP00000445835 ENST00000545495	O75618 [Direct mapping] Death effector domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0042981 [regulation of apoptotic process] Show all	318 aa 36.8 kDa	No	0