Cell atlas - EDA - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EDA
Gene description	Ectodysplasin A
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the lipid droplets.
RNA cell category	Cell line enhanced (Hep G2, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Lipid droplets (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA037972 , HPA037973
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the lipid droplets.

Main location

Vesicles (supported)

Additional location

Lipid droplets (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037972	HEK 293	Vesicles
HPA037972	U-2 OS	No staining
HPA037973	HEK 293	Vesicles
HPA037973	Hep G2	Lipid droplets
HPA037973	U-2 OS	No staining

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000059327 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA037973	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	EDA (HGNC Symbol)
Synonyms	ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, ODT1, XHED, XLHED
Description	Ectodysplasin A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q13.1
Chromosome location (bp)	69616067 - 70039469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158813 (version 83.38)
Entrez gene	1896
UniProt	Q92838 (UniProt - Evidence at protein level)
neXtProt	NX_Q92838
Antibodypedia	EDA antibodies

PROTEIN BROWSER

EDA-001	EDA-002	EDA-005	EDA-007	EDA-008	EDA-009	EDA-012	EDA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDA-001 ENSP00000363681 ENST00000374553	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	389 aa 41.1 kDa	No	1
EDA-002 ENSP00000363680 ENST00000374552	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0001942 [hair follicle development] GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005789 [endoplasmic reticulum membrane] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0043473 [pigmentation] GO:0043588 [skin development] GO:0045177 [apical part of cell] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060662 [salivary gland cavitation] GO:0060789 [hair follicle placode formation] GO:0061153 [trachea gland development] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	391 aa 41.3 kDa	No	1
EDA-005 ENSP00000423037 ENST00000503592	D6RA95 [Direct mapping] Ectodysplasin-A Show all	Predicted intracellular proteins Show all		137 aa 13.8 kDa	No	0
EDA-007 ENSP00000434195 ENST00000525810	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	135 aa 14 kDa	No	1
EDA-008 ENSP00000432585 ENST00000524573	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	386 aa 40.7 kDa	No	1
EDA-009 ENSP00000434861 ENST00000527388	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	148 aa 15.6 kDa	No	1
EDA-012 ENSP00000340611 ENST00000338901	Q92838 [Direct mapping] Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005102 [receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007398 [ectoderm development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	147 aa 15.1 kDa	No	1
EDA-201 ENSP00000481963 ENST00000616899	A0A0C4DGX3 [Direct mapping] Ectodysplasin-A; HCG14664 Show all	Predicted intracellular proteins Show all	GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] Show all	259 aa 27.6 kDa	No	0