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B4GALT3

CANCER ATLAS

Gene description

 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010793

GENE INFORMATION

Gene name

 B4GALT3 (HGNC Symbol)

Synonyms

 beta4Gal-T3

Description

 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 (HGNC Symbol)

Entrez gene summary

 This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161171310 - 161177968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158850 (version 83.38)

Entrez gene

 8703

UniProt

 O60512 (UniProt - Evidence at protein level)

neXtProt

 NX_O60512

Antibodypedia

 B4GALT3 antibodies

PROTEIN BROWSER
B4GALT3-001
B4GALT3-002
B4GALT3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
B4GALT3-001
ENSP00000320965
ENST00000319769
O60512 [Direct mapping]
Beta-1,4-galactosyltransferase 3 N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity]
GO:0003945 [N-acetyllactosamine synthase activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0008378 [galactosyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0032580 [Golgi cisterna membrane]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 393 aa
43.9 kDa 		No 0
B4GALT3-002
ENSP00000356977
ENST00000367998
O60512 [Direct mapping]
Beta-1,4-galactosyltransferase 3 N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity]
GO:0003945 [N-acetyllactosamine synthase activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0008378 [galactosyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0032580 [Golgi cisterna membrane]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 393 aa
43.9 kDa 		No 0
B4GALT3-201
ENSP00000480428
ENST00000622395
O60512 [Direct mapping]
Beta-1,4-galactosyltransferase 3 N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity]
GO:0003945 [N-acetyllactosamine synthase activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0008378 [galactosyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0032580 [Golgi cisterna membrane]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 393 aa
43.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.