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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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APOA2
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    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

APOA2

Gene description

Apolipoprotein A-II

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Extracellular deposits (plasma) in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 1 antibody.
CAB025885
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

APOA2

Synonyms

Description

Apolipoprotein A-II (HGNC Symbol)

Entrez gene summary

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161222292 - 161223631

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158874 (version 83.38)

Entrez gene

336

UniProt

P02652 (UniProt - Evidence at protein level)

neXtProt

NX_P02652

Antibodypedia

APOA2 antibodies

PROTEIN BROWSER

APOA2-001
APOA2-002
APOA2-004
APOA2-005
APOA2-007
APOA2-008
APOA2-009
APOA2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOA2-001
ENSP00000356969
ENST00000367990
P02652 [Direct mapping]
Apolipoprotein A-II Proapolipoprotein A-II Truncated apolipoprotein A-II
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002526 [acute inflammatory response]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006641 [triglyceride metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006869 [lipid transport]
GO:0007603 [phototransduction, visible light]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0009395 [phospholipid catabolic process]
GO:0009749 [response to glucose]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0016032 [viral process]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031100 [organ regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031647 [regulation of protein stability]
GO:0032375 [negative regulation of cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034190 [apolipoprotein receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034370 [triglyceride-rich lipoprotein particle remodeling]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0042157 [lipoprotein metabolic process]
GO:0042493 [response to drug]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0043627 [response to estrogen]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0046340 [diacylglycerol catabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051384 [response to glucocorticoid]
GO:0055102 [lipase inhibitor activity]
GO:0060192 [negative regulation of lipase activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060621 [negative regulation of cholesterol import]
GO:0060695 [negative regulation of cholesterol transporter activity]
GO:0070062 [extracellular exosome]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0072562 [blood microparticle]
Show all
100 aa
11.2 kDa
Yes 0
APOA2-002
ENSP00000477353
ENST00000491350
Q76EI7 [Direct mapping]
Apolipoprotein A-II
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
27 aa
2.9 kDa
Yes 0
APOA2-004
ENSP00000476662
ENST00000468465
V9GYE3 [Direct mapping]
Apolipoprotein A-II
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
52 aa
5.9 kDa
No 0
APOA2-005
ENSP00000476890
ENST00000463812
V9GYE3 [Direct mapping]
Apolipoprotein A-II
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
52 aa
5.9 kDa
No 0
APOA2-007
ENSP00000477031
ENST00000470459
V9GYS1 [Direct mapping]
Apolipoprotein A-II
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
82 aa
9.2 kDa
Yes 0
APOA2-008
ENSP00000476911
ENST00000464492
V9GYM3 [Direct mapping]
Apolipoprotein A-II
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
133 aa
14.9 kDa
No 0
APOA2-009
ENSP00000476605
ENST00000469730
V9GYC1 [Direct mapping]
Apolipoprotein A-II
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
66 aa
7.4 kDa
Yes 0
APOA2-010
ENSP00000476740
ENST00000463273
V9GYG9 [Direct mapping]
Apolipoprotein A-II
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
95 aa
10.6 kDa
Yes 0

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