Expression of FBXW5 in cancer - Summary

CANCER ATLAS

Gene description

F-box and WD repeat domain containing 5

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046615

GENE INFORMATION
Gene name	FBXW5 (HGNC Symbol)
Synonyms	DKFZP434B205, Fbw5, MGC20962
Description	F-box and WD repeat domain containing 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136940435 - 136944696
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159069 (version 83.38)
Entrez gene	54461
UniProt	Q969U6 (UniProt - Evidence at protein level)
neXtProt	NX_Q969U6
Antibodypedia	FBXW5 antibodies

PROTEIN BROWSER

FBXW5-001	FBXW5-004	FBXW5-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXW5-001 ENSP00000313034 ENST00000325285	Q969U6 [Direct mapping] F-box/WD repeat-containing protein 5 A0A024R8H7 [Target identity:100%; Query identity:100%] F-box and WD-40 domain protein 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0019901 [protein kinase binding] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051298 [centrosome duplication] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	566 aa 63.9 kDa	No	0
FBXW5-004 ENSP00000394011 ENST00000443788	A0A0A0MSK7 [Direct mapping] F-box/WD repeat-containing protein 5 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	129 aa 15 kDa	No	0
FBXW5-008 ENSP00000404829 ENST00000428398	A0A0A0MSV8 [Direct mapping] F-box/WD repeat-containing protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	200 aa 22.7 kDa	No	0