Expression of IFNAR2 in cancer - Summary

CANCER ATLAS

Gene description

Interferon (alpha, beta and omega) receptor 2

Protein class

Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025889

GENE INFORMATION
Gene name	IFNAR2 (HGNC Symbol)
Synonyms	IFNABR
Description	Interferon (alpha, beta and omega) receptor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33229901 - 33265675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159110 (version 83.38)
Entrez gene	3455
UniProt	P48551 (UniProt - Evidence at protein level)
neXtProt	NX_P48551
Antibodypedia	IFNAR2 antibodies

PROTEIN BROWSER

IFNAR2-001	IFNAR2-002	IFNAR2-003	IFNAR2-004	IFNAR2-008	IFNAR2-009	IFNAR2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNAR2-001 ENSP00000384309 ENST00000404220	P48551 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004905 [type I interferon receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007259 [JAK-STAT cascade] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019962 [type I interferon binding] GO:0035455 [response to interferon-alpha] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	331 aa 37.4 kDa	No	1
IFNAR2-002 ENSP00000343957 ENST00000342136	P48551 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004905 [type I interferon receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007166 [cell surface receptor signaling pathway] GO:0007259 [JAK-STAT cascade] GO:0008283 [cell proliferation] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019962 [type I interferon binding] GO:0035455 [response to interferon-alpha] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	515 aa 57.8 kDa	No	2
IFNAR2-003 ENSP00000343289 ENST00000342101	P48551 [Direct mapping] Interferon alpha/beta receptor 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004905 [type I interferon receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007259 [JAK-STAT cascade] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019962 [type I interferon binding] GO:0035455 [response to interferon-alpha] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	239 aa 27.4 kDa	No	0
IFNAR2-004 ENSP00000371699 ENST00000382264	P48551 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004905 [type I interferon receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007259 [JAK-STAT cascade] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019962 [type I interferon binding] GO:0035455 [response to interferon-alpha] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	331 aa 37.4 kDa	No	1
IFNAR2-008 ENSP00000402311 ENST00000447980	C9JM33 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	204 aa 23.5 kDa	No	1
IFNAR2-009 ENSP00000413160 ENST00000413881	C9K067 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0019221 [cytokine-mediated signaling pathway] Show all	167 aa 19 kDa	No	0
IFNAR2-010 ENSP00000403569 ENST00000443073	C9JCU0 [Direct mapping] Interferon alpha/beta receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	229 aa 25.8 kDa	No	1