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LAD1

GENERAL INFORMATION

Gene name

 LAD1

Gene description

 Ladinin 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Tissue enhanced (esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression mainly in squamous and glandular epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA007256 , HPA028732
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)

GENE INFORMATION

Gene name

 LAD1

Synonyms

Description

 Ladinin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 201373244 - 201399915

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159166 (version 83.38)

Entrez gene

 3898

UniProt

 O00515 (UniProt - Evidence at protein level)

neXtProt

 NX_O00515

Antibodypedia

 LAD1 antibodies

PROTEIN BROWSER
LAD1-001
LAD1-002
LAD1-005
LAD1-006
LAD1-007
LAD1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAD1-001
ENSP00000375829
ENST00000391967
O00515 [Direct mapping]
Ladinin-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005604 [basement membrane]
GO:0070062 [extracellular exosome]
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 517 aa
57.1 kDa 		No 0
LAD1-002
ENSP00000356282
ENST00000367313
E9PDI4 [Direct mapping]
Ladinin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 531 aa
58.7 kDa 		No 0
LAD1-005
ENSP00000422687
ENST00000503578
H0Y901 [Direct mapping]
Ladinin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 192 aa
21.5 kDa 		No 0
LAD1-006
ENSP00000488829
ENST00000631576
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 183 aa
21.1 kDa 		No 0
LAD1-007
ENSP00000487828
ENST00000632743
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 188 aa
21.7 kDa 		No 0
LAD1-008
ENSP00000487726
ENST00000633953
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 178 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.