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A majority of cancer tissues showed a weak to moderate cytoplasmic positivity with distinct extracellular staining. Several cases of ovarian cancers and a few cases of prostate, testis, urothelial and renal cancers displayed moderate cytoplasmic immunoreactivity with distinct extracellular staining.
GENE INFORMATION
Gene name
STC1 (HGNC Symbol)
Synonyms
STC
Description
Stanniocalcin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001503 [ossification] GO:0001886 [endothelial cell morphogenesis] GO:0003421 [growth plate cartilage axis specification] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006874 [cellular calcium ion homeostasis] GO:0007566 [embryo implantation] GO:0010596 [negative regulation of endothelial cell migration] GO:0014070 [response to organic cyclic compound] GO:0016324 [apical plasma membrane] GO:0030336 [negative regulation of cell migration] GO:0033280 [response to vitamin D] GO:0035988 [chondrocyte proliferation] GO:0044070 [regulation of anion transport] GO:0046697 [decidualization] GO:0051926 [negative regulation of calcium ion transport] GO:0060348 [bone development] GO:0071320 [cellular response to cAMP] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071456 [cellular response to hypoxia] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0090280 [positive regulation of calcium ion import] GO:1903403 [negative regulation of renal phosphate excretion]
