Cell atlas - TNNI1 - The Human Protein Atlas

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TNNI1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TNNI1
Gene description	Troponin I type 1 (skeletal, slow)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli.
RNA cell category	Cell line enriched (RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain)
Additional location	In addition localized to the Nucleoli (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA028190
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

Nucleus (uncertain)

Additional location

Nucleoli (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028190	RH-30	Nucleus
	HPA028190	RH-30	Nucleoli
	HPA028190	U-2 OS	Nucleus
	HPA028190	U-2 OS	Nucleoli
	HPA028190	U-251 MG	Nucleoplasm
	HPA028190	U-251 MG	Nucleoli fibrillar center	Spatial

GENE INFORMATION
Gene name	TNNI1
Synonyms
Description	Troponin I type 1 (skeletal, slow) (HGNC Symbol)
Entrez gene summary	Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	201403768 - 201429866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159173 (version 83.38)
Entrez gene	7135
UniProt	P19237 (UniProt - Evidence at protein level)
neXtProt	NX_P19237
Antibodypedia	TNNI1 antibodies

PROTEIN BROWSER

TNNI1-001	TNNI1-002	TNNI1-003	TNNI1-004	TNNI1-005	TNNI1-006	TNNI1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNNI1-001 ENSP00000354488 ENST00000361379	P19237 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] GO:0006942 [regulation of striated muscle contraction] GO:0014883 [transition between fast and slow fiber] GO:0030049 [muscle filament sliding] GO:0046872 [metal ion binding] GO:0055010 [ventricular cardiac muscle tissue morphogenesis] GO:0060048 [cardiac muscle contraction] Show all	187 aa 21.7 kDa	No	0
TNNI1-002 ENSP00000337022 ENST00000336092	P19237 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006942 [regulation of striated muscle contraction] GO:0030049 [muscle filament sliding] GO:0046872 [metal ion binding] GO:0060048 [cardiac muscle contraction] Show all	187 aa 21.7 kDa	No	0
TNNI1-003 ENSP00000356281 ENST00000367312	P19237 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006942 [regulation of striated muscle contraction] GO:0030049 [muscle filament sliding] GO:0046872 [metal ion binding] GO:0060048 [cardiac muscle contraction] Show all	187 aa 21.7 kDa	No	0
TNNI1-004 ENSP00000451776 ENST00000556362	G3V4F8 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] Show all	137 aa 16 kDa	No	0
TNNI1-005 ENSP00000451660 ENST00000555340	G3V489 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] Show all	131 aa 15.3 kDa	No	0
TNNI1-006 ENSP00000451307 ENST00000555948	G3V3L5 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] Show all	105 aa 12.1 kDa	No	0
TNNI1-201 ENSP00000477578 ENST00000622580	A0A087WT47 [Direct mapping] Troponin I, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] Show all	187 aa 21.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.