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Most cancer tissues showed weak to moderate cytoplasmic and additional membranous staining in many cases. A few non-Hodgkins lymphomas and colorectal cancers were strongly stained. Melanomas, breast, testis, urothelial, liver and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CSRP1 (HGNC Symbol)
Synonyms
CSRP, CYRP, D1S181E
Description
Cysteine and glycine-rich protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]