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C1QC

GENERAL INFORMATION

Gene name

 C1QC

Gene description

 Complement component 1, q subcomponent, C chain

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly plasma positivity.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA001471 , CAB009828
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 C1QC (HGNC Symbol)

Synonyms

 C1QG

Description

 Complement component 1, q subcomponent, C chain (HGNC Symbol)

Entrez gene summary

 This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 22643630 - 22648110

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159189 (version 83.38)

Entrez gene

 714

UniProt

 P02747 (UniProt - Evidence at protein level)

neXtProt

 NX_P02747

Antibodypedia

 C1QC antibodies

PROTEIN BROWSER
C1QC-001
C1QC-002
C1QC-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C1QC-001
ENSP00000363770
ENST00000374639
P02747 [Direct mapping]
Complement C1q subcomponent subunit C
A0A024RAA7 [Target identity:100%; Query identity:100%]
Complement component 1, q subcomponent, C chain, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0045087 [innate immune response]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 245 aa
25.8 kDa 		Yes 0
C1QC-002
ENSP00000363768
ENST00000374637
P02747 [Direct mapping]
Complement C1q subcomponent subunit C
A0A024RAA7 [Target identity:100%; Query identity:100%]
Complement component 1, q subcomponent, C chain, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0045087 [innate immune response]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 245 aa
25.8 kDa 		Yes 0
C1QC-003
ENSP00000363771
ENST00000374640
P02747 [Direct mapping]
Complement C1q subcomponent subunit C
A0A024RAA7 [Target identity:100%; Query identity:100%]
Complement component 1, q subcomponent, C chain, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0045087 [innate immune response]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
 245 aa
25.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.