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RCAN1

GENERAL INFORMATION

Gene name

 RCAN1

Gene description

 Regulator of calcineurin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Uncertain based on 1 antibody.
CAB037218
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RCAN1 (HGNC Symbol)

Synonyms

 DSCR1

Description

 Regulator of calcineurin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Chromosome

 21

Cytoband

 q22.12

Chromosome location (bp)

 34513142 - 34615142

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159200 (version 83.38)

Entrez gene

 1827

UniProt

 P53805 (UniProt - Evidence at protein level)

neXtProt

 NX_P53805

Antibodypedia

 RCAN1 antibodies

PROTEIN BROWSER
RCAN1-001
RCAN1-003
RCAN1-004
RCAN1-005
RCAN1-006
RCAN1-007
RCAN1-010
RCAN1-201
RCAN1-202
RCAN1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RCAN1-001
ENSP00000320768
ENST00000313806
P53805 [Direct mapping]
Calcipressin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 252 aa
28.1 kDa 		No 0
RCAN1-003
ENSP00000370524
ENST00000381132
P53805 [Direct mapping]
Calcipressin-1
Q6FGP2 [Target identity:100%; Query identity:100%]
DSCR1 protein; Down syndrome critical region gene 1, isoform CRA_b; cDNA FLJ55243, highly similar to Calcipressin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 197 aa
22.8 kDa 		No 0
RCAN1-004
ENSP00000382214
ENST00000399272
P53805 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 171 aa
19.8 kDa 		No 0
RCAN1-005
ENSP00000417926
ENST00000481448
E9PD55 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 242 aa
27.8 kDa 		No 0
RCAN1-006
ENSP00000419624
ENST00000482533
P53805 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 117 aa
13.3 kDa 		No 0
RCAN1-007
ENSP00000477155
ENST00000492600
V9GYW9 [Direct mapping]
Calcipressin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 205 aa
23.2 kDa 		No 0
RCAN1-010
ENSP00000419252
ENST00000487990
P53805 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 117 aa
13.3 kDa 		No 0
RCAN1-201
ENSP00000370527
ENST00000381135
E9PDJ2 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002931 [response to ischemia]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006979 [response to oxidative stress]
GO:0007519 [skeletal muscle tissue development]
GO:0007614 [short-term memory]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0009612 [response to mechanical stimulus]
GO:0019722 [calcium-mediated signaling]
GO:0031987 [locomotion involved in locomotory behavior]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0043627 [response to estrogen]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0048741 [skeletal muscle fiber development]
GO:0051151 [negative regulation of smooth muscle cell differentiation]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 277 aa
31.9 kDa 		No 0
RCAN1-202
ENSP00000392438
ENST00000443408
P53805 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 117 aa
13.3 kDa 		No 0
RCAN1-203
ENSP00000477646
ENST00000620920
P53805 [Direct mapping]
Calcipressin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008015 [blood circulation]
GO:0008597 [calcium-dependent protein serine/threonine phosphatase regulator activity]
GO:0019722 [calcium-mediated signaling]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0042802 [identical protein binding]
GO:0050790 [regulation of catalytic activity]
GO:0070884 [regulation of calcineurin-NFAT signaling cascade]
Show all
 117 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.