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Moderate to strong cytoplasmic positivity was observed in several cases of hepatocellular carcinomas, pancreatic, gastric, colorectal and ovarian cancers. Other malignancies were in general weakly stained or negative.
GENE INFORMATION
Gene name
GIP
Synonyms
Description
Gastric inhibitory polypeptide (HGNC Symbol)
Entrez gene summary
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]