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CBR3

GENERAL INFORMATION

Gene name

 CBR3

Gene description

 Carbonyl reductase 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA018434
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CBR3 (HGNC Symbol)

Synonyms

 SDR21C2

Description

 Carbonyl reductase 3 (HGNC Symbol)

Entrez gene summary

 Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.12

Chromosome location (bp)

 36134912 - 36146566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159231 (version 83.38)

Entrez gene

 874

UniProt

 O75828 (UniProt - Evidence at protein level)

neXtProt

 NX_O75828

Antibodypedia

 CBR3 antibodies

PROTEIN BROWSER
CBR3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBR3-001
ENSP00000290354
ENST00000290354
O75828 [Direct mapping]
Carbonyl reductase [NADPH] 3
V9HW40 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 25
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0042376 [phylloquinone catabolic process]
GO:0050890 [cognition]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
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 277 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.