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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ACTC1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACTC1

Gene description

Actin, alpha, cardiac muscle 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (heart muscle)
GTEx:Tissue enriched (heart muscle)
FANTOM5:Tissue enhanced (heart muscle, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in heart, skeletal and smooth muscle.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 4 antibodies.
HPA041264 , HPA041271 , CAB003761 , CAB037330
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, smooth muscle)

GENE INFORMATION

Gene name

ACTC1 (HGNC Symbol)

Synonyms

ACTC, CMD1R

Description

Actin, alpha, cardiac muscle 1 (HGNC Symbol)

Entrez gene summary

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q14

Chromosome location (bp)

34788096 - 34796139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159251 (version 83.38)

Entrez gene

70

UniProt

P68032 (UniProt - Evidence at protein level)

neXtProt

NX_P68032

Antibodypedia

ACTC1 antibodies

PROTEIN BROWSER

ACTC1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTC1-001
ENSP00000290378
ENST00000290378
P68032 [Direct mapping]
Actin, alpha cardiac muscle 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0017022 [myosin binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0030175 [filopodium]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0031032 [actomyosin structure organization]
GO:0031674 [I band]
GO:0033275 [actin-myosin filament sliding]
GO:0042493 [response to drug]
GO:0042643 [actomyosin, actin portion]
GO:0043066 [negative regulation of apoptotic process]
GO:0044297 [cell body]
GO:0045471 [response to ethanol]
GO:0055003 [cardiac myofibril assembly]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0060047 [heart contraction]
GO:0060048 [cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:0070252 [actin-mediated cell contraction]
GO:0072562 [blood microparticle]
GO:0090131 [mesenchyme migration]
Show all
377 aa
42 kDa
No 0

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