Tissue expression of CLDN14 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLDN14
Gene description	Claudin 14
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (liver, kidney)
GTEx:	Group enriched (liver, kidney)
FANTOM5:	Group enriched (liver, kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)

GENE INFORMATION
Gene name	CLDN14 (HGNC Symbol)
Synonyms	DFNB29
Description	Claudin 14 (HGNC Symbol)
Entrez gene summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	21
Cytoband	q22.13
Chromosome location (bp)	36460621 - 36576569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159261 (version 83.38)
Entrez gene	23562
UniProt	O95500 (UniProt - Evidence at protein level)
neXtProt	NX_O95500
Antibodypedia	CLDN14 antibodies

PROTEIN BROWSER

CLDN14-001	CLDN14-002	CLDN14-003	CLDN14-004	CLDN14-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN14-001 ENSP00000382090 ENST00000399137	O95500 [Direct mapping] Claudin-14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	239 aa 25.7 kDa	No	3
CLDN14-002 ENSP00000382087 ENST00000399135	O95500 [Direct mapping] Claudin-14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005198 [structural molecule activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	239 aa 25.7 kDa	No	3
CLDN14-003 ENSP00000382088 ENST00000399136	O95500 [Direct mapping] Claudin-14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005198 [structural molecule activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	239 aa 25.7 kDa	No	3
CLDN14-004 ENSP00000339292 ENST00000342108	O95500 [Direct mapping] Claudin-14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005198 [structural molecule activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	239 aa 25.7 kDa	No	3
CLDN14-006 ENSP00000382092 ENST00000399139	O95500 [Direct mapping] Claudin-14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005198 [structural molecule activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	239 aa 25.7 kDa	No	3