Expression of UBR1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ubiquitin protein ligase E3 component n-recognin 1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038838

GENE INFORMATION
Gene name	UBR1
Synonyms
Description	Ubiquitin protein ligase E3 component n-recognin 1 (HGNC Symbol)
Entrez gene summary	The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.2
Chromosome location (bp)	42942897 - 43106113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159459 (version 83.38)
Entrez gene	197131
UniProt	Q8IWV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWV7
Antibodypedia	UBR1 antibodies

PROTEIN BROWSER

UBR1-001	UBR1-002	UBR1-005	UBR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBR1-001 ENSP00000290650 ENST00000290650	Q8IWV7 [Direct mapping] E3 ubiquitin-protein ligase UBR1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000502 [proteasome complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030163 [protein catabolic process] GO:0032007 [negative regulation of TOR signaling] GO:0061630 [ubiquitin protein ligase activity] GO:0070728 [leucine binding] GO:0071233 [cellular response to leucine] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	1749 aa 200.2 kDa	No	0
UBR1-002 ENSP00000477932 ENST00000546274	A0A087WTJ9 [Direct mapping] E3 ubiquitin-protein ligase UBR1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0030163 [protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	1070 aa 124.1 kDa	No	0
UBR1-005 ENSP00000457573 ENST00000569243	H3BUC4 [Direct mapping] E3 ubiquitin-protein ligase UBR1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	172 aa 19.9 kDa	No	0
UBR1-201 ENSP00000486206 ENST00000627960	H3BNQ6 [Direct mapping] E3 ubiquitin-protein ligase UBR1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	62 aa 6.7 kDa	No	0