Cell atlas - TPPP3 - The Human Protein Atlas

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TPPP3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	TPPP3
Gene description	Tubulin polymerization-promoting protein family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (SCLC-21H, A549, RH-30, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047629
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, A549, RH-30, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047629	A549	Nucleoli fibrillar center
	HPA047629	HEK 293	Nucleoli fibrillar center
	HPA047629	U-2 OS	Nucleoli fibrillar center

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000014846 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA047629	NIH 3T3	No staining

GENE INFORMATION
Gene name	TPPP3 (HGNC Symbol)
Synonyms	CGI-38, p20, p25gamma
Description	Tubulin polymerization-promoting protein family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67389809 - 67393535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159713 (version 83.38)
Entrez gene	51673
UniProt	Q9BW30 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BW30
Antibodypedia	TPPP3 antibodies

PROTEIN BROWSER

TPPP3-001	TPPP3-002	TPPP3-003	TPPP3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPPP3-001 ENSP00000377529 ENST00000393957	Q9BW30 [Direct mapping] Tubulin polymerization-promoting protein family member 3 A0A024R702 [Target identity:100%; Query identity:100%] Brain specific protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001578 [microtubule bundle formation] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0015631 [tubulin binding] GO:0046785 [microtubule polymerization] GO:0070062 [extracellular exosome] Show all	176 aa 19 kDa	No	0
TPPP3-002 ENSP00000290942 ENST00000290942	Q9BW30 [Direct mapping] Tubulin polymerization-promoting protein family member 3 A0A024R702 [Target identity:100%; Query identity:100%] Brain specific protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001578 [microtubule bundle formation] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0015631 [tubulin binding] GO:0046785 [microtubule polymerization] GO:0070062 [extracellular exosome] Show all	176 aa 19 kDa	No	0
TPPP3-003 ENSP00000462435 ENST00000564104	Q9BW30 [Direct mapping] Tubulin polymerization-promoting protein family member 3 A0A024R702 [Target identity:100%; Query identity:100%] Brain specific protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001578 [microtubule bundle formation] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0015631 [tubulin binding] GO:0046785 [microtubule polymerization] GO:0070062 [extracellular exosome] Show all	176 aa 19 kDa	No	0
TPPP3-004 ENSP00000457275 ENST00000562206	Q9BW30 [Direct mapping] Tubulin polymerization-promoting protein family member 3 A0A024R702 [Target identity:100%; Query identity:100%] Brain specific protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001578 [microtubule bundle formation] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0015631 [tubulin binding] GO:0046785 [microtubule polymerization] GO:0070062 [extracellular exosome] Show all	176 aa 19 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.