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ATP6V0D1

GENERAL INFORMATION

Gene name

 ATP6V0D1

Gene description

 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at varying levels in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA016938
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP6V0D1 (HGNC Symbol)

Synonyms

 ATP6D, ATP6DV, P39, VATX, Vma6, VPATPD

Description

 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67438014 - 67481237

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159720 (version 83.38)

Entrez gene

 9114

UniProt

 P61421 (UniProt - Evidence at protein level)

neXtProt

 NX_P61421

Antibodypedia

 ATP6V0D1 antibodies

PROTEIN BROWSER
ATP6V0D1-001
ATP6V0D1-002
ATP6V0D1-015
ATP6V0D1-017
ATP6V0D1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V0D1-001
ENSP00000290949
ENST00000290949
P61421 [Direct mapping]
V-type proton ATPase subunit d 1
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005813 [centrosome]
GO:0006879 [cellular iron ion homeostasis]
GO:0007420 [brain development]
GO:0008021 [synaptic vesicle]
GO:0008286 [insulin receptor signaling pathway]
GO:0008553 [hydrogen-exporting ATPase activity, phosphorylative mechanism]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032403 [protein complex binding]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042384 [cilium assembly]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0043679 [axon terminus]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 351 aa
40.3 kDa 		No 0
ATP6V0D1-002
ENSP00000441282
ENST00000540149
F5GYQ1 [Direct mapping]
V-type proton ATPase subunit d 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 392 aa
44.7 kDa 		No 0
ATP6V0D1-015
ENSP00000463328
ENST00000565835
J3QL14 [Direct mapping]
V-type proton ATPase subunit d 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 232 aa
26.7 kDa 		No 0
ATP6V0D1-017
ENSP00000455802
ENST00000564615
H3BQJ1 [Direct mapping]
V-type proton ATPase subunit d 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 227 aa
25.5 kDa 		No 0
ATP6V0D1-201
ENSP00000473515
ENST00000602876
R4GN72 [Direct mapping]
V-type proton ATPase subunit d 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 274 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.