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RGS12

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GENERAL INFORMATION

Gene name

 RGS12

Gene description

 Regulator of G-protein signaling 12

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nucleoli.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA054646 , HPA067421
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nucleoli.

Main location

 Nucleus (supported), Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA054646 PC-3 Nucleus
Nucleoli
Cytosol
HPA054646 U-2 OS Nucleus
Nucleoli
Cytosol
HPA054646 U-251 MG Nucleus
Nucleoli
Cytosol
HPA067421 RT4 Nucleus
HPA067421 SK-MEL-30 Nucleus
HPA067421 U-2 OS Nucleus
Nucleoli

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000029101 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA054646 NIH 3T3 No staining

GENE INFORMATION

Gene name

 RGS12

Synonyms

Description

 Regulator of G-protein signaling 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 3293028 - 3439913

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159788 (version 83.38)

Entrez gene

 6002

UniProt

 O14924 (UniProt - Evidence at protein level)

neXtProt

 NX_O14924

Antibodypedia

 RGS12 antibodies

PROTEIN BROWSER
RGS12-001
RGS12-002
RGS12-003
RGS12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS12-001
ENSP00000339381
ENST00000344733
O14924 [Direct mapping]
Regulator of G-protein signaling 12
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0001965 [G-protein alpha-subunit binding]
GO:0005057 [receptor signaling protein activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016363 [nuclear matrix]
GO:0030695 [GTPase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038032 [termination of G-protein coupled receptor signaling pathway]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0050790 [regulation of catalytic activity]
GO:0097440 [apical dendrite]
Show all
 1447 aa
156.4 kDa 		No 0
RGS12-002
ENSP00000372238
ENST00000382788
O14924 [Direct mapping]
Regulator of G-protein signaling 12
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0005057 [receptor signaling protein activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016363 [nuclear matrix]
GO:0030695 [GTPase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
Show all
 1376 aa
149.6 kDa 		No 0
RGS12-003
ENSP00000342133
ENST00000338806
O14924 [Direct mapping]
Regulator of G-protein signaling 12
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0005057 [receptor signaling protein activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016363 [nuclear matrix]
GO:0030695 [GTPase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
Show all
 799 aa
86 kDa 		No 0
RGS12-201
ENSP00000338509
ENST00000336727
O14924 [Direct mapping]
Regulator of G-protein signaling 12
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0005057 [receptor signaling protein activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016363 [nuclear matrix]
GO:0030695 [GTPase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
Show all
 1447 aa
156.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.